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Correspondence Address: Ritu M Gilhotra Head of Department, Department of Pharmaceutics, School of Pharmacy, Suresh Gyan Vihar University, Jaipur, Rajasthan India Source of Support: None, Conflict of Interest: None The development of a bioavailable dosage form is the most challenging task for the researchers.In the arena of advanced drug delivery systems, the solid dispersion techniques seem to be a promising system for the development of an optimized, bioavailable formulation of Class 2 drugs.
The prospective of the stability of solid dispersion has also been discussed.
Moreover, the major techniques that have been used so far such as the fusion/melting method, solvent evaporation method, hot melt extrusion method, supercritical fluid methods, have also been detailed.
A pharmaceutical literature survey related to solid dispersions revealed that the dissolution behavior of a number of poorly water-soluble drugs have been altered with the help of solid dispersion techniques.
The oral bioavailability of Class 2 drugs can be increased.
The better side of a crystalline matrix is that diffusion will be very slow and so degradation.
Literature shows that such solid dispersions show poor dissolution characteristics on storage.
Development of an optimized, bioavailable formulation of a particular drug is a Herculean task.
40% of the drugs newly synthesized by the chemists belong to the category of poorly soluble drugs.
Class 1 drugs dissolve rapidly in an aqueous environment and are rapidly transported over the absorbing membrane.
From the point of view of a formulator, these types of drugs are perfect candidates and new strategies are not to be devised for them.